Deep sequencing shows that HBV basal core promoter and precore variants reduce the likelihood of HBsAg loss following tenofovir disoproxil fumarate therapy in HBeAg-positive chronic hepatitis B.
Identifieur interne : 000E67 ( Main/Exploration ); précédent : 000E66; suivant : 000E68Deep sequencing shows that HBV basal core promoter and precore variants reduce the likelihood of HBsAg loss following tenofovir disoproxil fumarate therapy in HBeAg-positive chronic hepatitis B.
Auteurs : Julianne Bayliss [Australie] ; Lilly Yuen [Australie] ; Gillian Rosenberg [Australie] ; Darren Wong [Australie] ; Margaret Littlejohn [Australie] ; Kathleen Jackson [Australie] ; Anuj Gaggar [États-Unis] ; Kathryn M. Kitrinos [États-Unis] ; G Mani Subramanian [États-Unis] ; Patrick Marcellin [France] ; Maria Buti [Espagne] ; Harry L A. Janssen [Canada] ; Ed Gane [Nouvelle-Zélande] ; Vitina Sozzi [Australie] ; Danni Colledge [Australie] ; Rachel Hammond [Australie] ; Rosalind Edwards [Australie] ; Stephen Locarnini [Australie] ; Alexander Thompson [Australie] ; Peter A. Revill [Australie]Source :
- Gut [ 1468-3288 ] ; 2017.
Descripteurs français
- KwdFr :
- ADN viral (analyse), Adulte, Adulte d'âge moyen, Analyse de séquence d'ADN, Antigènes de surface du virus de l'hépatite B (sang), Antigènes e du virus de l'hépatite virale B (sang), Antiviraux (usage thérapeutique), Charge virale, Femelle, Humains, Hépatite B chronique (sang), Hépatite B chronique (traitement médicamenteux), Hépatite B chronique (virologie), Marqueurs biologiques (sang), Mâle, Méthode en double aveugle, Régions promotrices (génétique), Résultat thérapeutique, Séquençage nucléotidique à haut débit, Séroconversion, Ténofovir (usage thérapeutique), Virus de l'hépatite B (génétique), Virus de l'hépatite B (immunologie).
- MESH :
- analyse : ADN viral.
- génétique : Virus de l'hépatite B.
- immunologie : Virus de l'hépatite B.
- sang : Antigènes de surface du virus de l'hépatite B, Antigènes e du virus de l'hépatite virale B, Hépatite B chronique, Marqueurs biologiques.
- traitement médicamenteux : Hépatite B chronique.
- usage thérapeutique : Antiviraux, Ténofovir.
- virologie : Hépatite B chronique.
- Adulte, Adulte d'âge moyen, Analyse de séquence d'ADN, Charge virale, Femelle, Humains, Mâle, Méthode en double aveugle, Régions promotrices (génétique), Résultat thérapeutique, Séquençage nucléotidique à haut débit, Séroconversion.
English descriptors
- KwdEn :
- Adult, Antiviral Agents (therapeutic use), Biomarkers (blood), DNA, Viral (analysis), Double-Blind Method, Female, Hepatitis B Surface Antigens (blood), Hepatitis B e Antigens (blood), Hepatitis B virus (genetics), Hepatitis B virus (immunology), Hepatitis B, Chronic (blood), Hepatitis B, Chronic (drug therapy), Hepatitis B, Chronic (virology), High-Throughput Nucleotide Sequencing, Humans, Male, Middle Aged, Promoter Regions, Genetic, Sequence Analysis, DNA, Seroconversion, Tenofovir (therapeutic use), Treatment Outcome, Viral Load.
- MESH :
- chemical , analysis : DNA, Viral.
- chemical , blood : Biomarkers, Hepatitis B Surface Antigens, Hepatitis B e Antigens.
- chemical , therapeutic use : Antiviral Agents, Tenofovir.
- blood : Hepatitis B, Chronic.
- drug therapy : Hepatitis B, Chronic.
- genetics : Hepatitis B virus.
- immunology : Hepatitis B virus.
- virology : Hepatitis B, Chronic.
- Adult, Double-Blind Method, Female, High-Throughput Nucleotide Sequencing, Humans, Male, Middle Aged, Promoter Regions, Genetic, Sequence Analysis, DNA, Seroconversion, Treatment Outcome, Viral Load.
Abstract
Hepatitis B e antigen (HBeAg) seroconversion and hepatitis B surface antigen (HBsAg) loss are important clinical outcomes for patients with chronic hepatitis B (CHB) treated with antiviral therapy. To date, there have been few studies that have evaluated viral sequence markers predicting serological response to nucleos(t)ide analogue (NA) treatment.
DOI: 10.1136/gutjnl-2015-309300
PubMed: 27534671
Affiliations:
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Le document en format XML
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Vitina" sort="Sozzi, Vitina" uniqKey="Sozzi V" first="Vitina" last="Sozzi">Vitina Sozzi</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Colledge, Danni" sort="Colledge, Danni" uniqKey="Colledge D" first="Danni" last="Colledge">Danni Colledge</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Hammond, Rachel" sort="Hammond, Rachel" uniqKey="Hammond R" first="Rachel" last="Hammond">Rachel Hammond</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Edwards, Rosalind" sort="Edwards, Rosalind" uniqKey="Edwards R" first="Rosalind" last="Edwards">Rosalind Edwards</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Locarnini, Stephen" sort="Locarnini, Stephen" uniqKey="Locarnini S" first="Stephen" last="Locarnini">Stephen Locarnini</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Thompson, Alexander" sort="Thompson, Alexander" uniqKey="Thompson A" first="Alexander" last="Thompson">Alexander Thompson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, St. Vincent's Hospital, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Gastroenterology, St. Vincent's Hospital, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Revill, Peter A" sort="Revill, Peter A" uniqKey="Revill P" first="Peter A" last="Revill">Peter A. Revill</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27534671</idno><idno type="pmid">27534671</idno><idno type="doi">10.1136/gutjnl-2015-309300</idno><idno type="wicri:Area/PubMed/Corpus">000224</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" 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last="Bayliss">Julianne Bayliss</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Yuen, Lilly" sort="Yuen, Lilly" uniqKey="Yuen L" first="Lilly" last="Yuen">Lilly Yuen</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Rosenberg, Gillian" sort="Rosenberg, Gillian" uniqKey="Rosenberg G" first="Gillian" last="Rosenberg">Gillian Rosenberg</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Darren" sort="Wong, Darren" uniqKey="Wong D" first="Darren" last="Wong">Darren Wong</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Littlejohn, Margaret" sort="Littlejohn, Margaret" uniqKey="Littlejohn M" first="Margaret" last="Littlejohn">Margaret Littlejohn</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Jackson, Kathleen" sort="Jackson, Kathleen" uniqKey="Jackson K" first="Kathleen" last="Jackson">Kathleen Jackson</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Gaggar, Anuj" sort="Gaggar, Anuj" uniqKey="Gaggar A" first="Anuj" last="Gaggar">Anuj Gaggar</name><affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gilead Sciences, Foster City, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kitrinos, Kathryn M" sort="Kitrinos, Kathryn M" uniqKey="Kitrinos K" first="Kathryn M" last="Kitrinos">Kathryn M. Kitrinos</name><affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gilead Sciences, Foster City, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Subramanian, G Mani" sort="Subramanian, G Mani" uniqKey="Subramanian G" first="G Mani" last="Subramanian">G Mani Subramanian</name><affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gilead Sciences, Foster City, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Marcellin, Patrick" sort="Marcellin, Patrick" uniqKey="Marcellin P" first="Patrick" last="Marcellin">Patrick Marcellin</name><affiliation wicri:level="1"><nlm:affiliation>Hôpital Beaujon, University of Paris, Clichy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Beaujon, University of Paris, Clichy</wicri:regionArea><wicri:noRegion>Clichy</wicri:noRegion><wicri:noRegion>Clichy</wicri:noRegion></affiliation></author><author><name sortKey="Buti, Maria" sort="Buti, Maria" uniqKey="Buti M" first="Maria" last="Buti">Maria Buti</name><affiliation wicri:level="3"><nlm:affiliation>Liver Unit, Valle d'Hebron (Ciberehd) University Hospital, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Liver Unit, Valle d'Hebron (Ciberehd) University Hospital, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Janssen, Harry L A" sort="Janssen, Harry L A" uniqKey="Janssen H" first="Harry L A" last="Janssen">Harry L A. Janssen</name><affiliation wicri:level="1"><nlm:affiliation>Toronto Center for Liver Diseases, Toronto Western and General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Center for Liver Diseases, Toronto Western and General Hospital, University Health Network, University of Toronto, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Gane, Ed" sort="Gane, Ed" uniqKey="Gane E" first="Ed" last="Gane">Ed Gane</name><affiliation wicri:level="1"><nlm:affiliation>New Zealand Liver Transplant Unit, Auckland City Hospital, Auckland, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>New Zealand Liver Transplant Unit, Auckland City Hospital, Auckland</wicri:regionArea><wicri:noRegion>Auckland</wicri:noRegion></affiliation></author><author><name sortKey="Sozzi, Vitina" sort="Sozzi, Vitina" uniqKey="Sozzi V" first="Vitina" last="Sozzi">Vitina Sozzi</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Colledge, Danni" sort="Colledge, Danni" uniqKey="Colledge D" first="Danni" last="Colledge">Danni Colledge</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Hammond, Rachel" sort="Hammond, Rachel" uniqKey="Hammond R" first="Rachel" last="Hammond">Rachel Hammond</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Edwards, Rosalind" sort="Edwards, Rosalind" uniqKey="Edwards R" first="Rosalind" last="Edwards">Rosalind Edwards</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Locarnini, Stephen" sort="Locarnini, Stephen" uniqKey="Locarnini S" first="Stephen" last="Locarnini">Stephen Locarnini</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Thompson, Alexander" sort="Thompson, Alexander" uniqKey="Thompson A" first="Alexander" last="Thompson">Alexander Thompson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, St. Vincent's Hospital, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Gastroenterology, St. Vincent's Hospital, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Revill, Peter A" sort="Revill, Peter A" uniqKey="Revill P" first="Peter A" last="Revill">Peter A. Revill</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author></analytic><series><title level="j">Gut</title><idno type="eISSN">1468-3288</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antiviral Agents (therapeutic use)</term><term>Biomarkers (blood)</term><term>DNA, Viral (analysis)</term><term>Double-Blind Method</term><term>Female</term><term>Hepatitis B Surface Antigens (blood)</term><term>Hepatitis B e Antigens (blood)</term><term>Hepatitis B virus (genetics)</term><term>Hepatitis B virus (immunology)</term><term>Hepatitis B, Chronic (blood)</term><term>Hepatitis B, Chronic (drug therapy)</term><term>Hepatitis B, Chronic (virology)</term><term>High-Throughput Nucleotide Sequencing</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Promoter Regions, Genetic</term><term>Sequence Analysis, DNA</term><term>Seroconversion</term><term>Tenofovir (therapeutic use)</term><term>Treatment Outcome</term><term>Viral Load</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN viral (analyse)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de séquence d'ADN</term><term>Antigènes de surface du virus de l'hépatite B (sang)</term><term>Antigènes e du virus de l'hépatite virale B (sang)</term><term>Antiviraux (usage thérapeutique)</term><term>Charge virale</term><term>Femelle</term><term>Humains</term><term>Hépatite B chronique (sang)</term><term>Hépatite B chronique (traitement médicamenteux)</term><term>Hépatite B chronique (virologie)</term><term>Marqueurs biologiques (sang)</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Régions promotrices (génétique)</term><term>Résultat thérapeutique</term><term>Séquençage nucléotidique à haut débit</term><term>Séroconversion</term><term>Ténofovir (usage thérapeutique)</term><term>Virus de l'hépatite B (génétique)</term><term>Virus de l'hépatite B (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>DNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Hepatitis B Surface Antigens</term><term>Hepatitis B e Antigens</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Tenofovir</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ADN viral</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Hepatitis B, Chronic</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hepatitis B, Chronic</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Hepatitis B virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus de l'hépatite B</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Virus de l'hépatite B</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Hepatitis B virus</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Antigènes de surface du virus de l'hépatite B</term><term>Antigènes e du virus de l'hépatite virale B</term><term>Hépatite B chronique</term><term>Marqueurs biologiques</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hépatite B chronique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Ténofovir</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Hépatite B chronique</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Hepatitis B, Chronic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Double-Blind Method</term><term>Female</term><term>High-Throughput Nucleotide Sequencing</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Promoter Regions, Genetic</term><term>Sequence Analysis, DNA</term><term>Seroconversion</term><term>Treatment Outcome</term><term>Viral Load</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de séquence d'ADN</term><term>Charge virale</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Régions promotrices (génétique)</term><term>Résultat thérapeutique</term><term>Séquençage nucléotidique à haut débit</term><term>Séroconversion</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hepatitis B e antigen (HBeAg) seroconversion and hepatitis B surface antigen (HBsAg) loss are important clinical outcomes for patients with chronic hepatitis B (CHB) treated with antiviral therapy. To date, there have been few studies that have evaluated viral sequence markers predicting serological response to nucleos(t)ide analogue (NA) treatment.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Nouvelle-Zélande</li><li>États-Unis</li></country><region><li>Californie</li><li>Catalogne</li></region><settlement><li>Barcelone</li></settlement></list><tree><country name="Australie"><noRegion><name sortKey="Bayliss, Julianne" sort="Bayliss, Julianne" uniqKey="Bayliss J" first="Julianne" last="Bayliss">Julianne Bayliss</name></noRegion><name sortKey="Colledge, Danni" sort="Colledge, Danni" uniqKey="Colledge D" first="Danni" last="Colledge">Danni Colledge</name><name sortKey="Edwards, Rosalind" sort="Edwards, Rosalind" uniqKey="Edwards R" first="Rosalind" last="Edwards">Rosalind Edwards</name><name sortKey="Hammond, Rachel" sort="Hammond, Rachel" uniqKey="Hammond R" first="Rachel" last="Hammond">Rachel Hammond</name><name sortKey="Jackson, Kathleen" sort="Jackson, Kathleen" uniqKey="Jackson K" first="Kathleen" last="Jackson">Kathleen Jackson</name><name sortKey="Littlejohn, Margaret" sort="Littlejohn, Margaret" uniqKey="Littlejohn M" first="Margaret" last="Littlejohn">Margaret Littlejohn</name><name sortKey="Locarnini, Stephen" sort="Locarnini, Stephen" uniqKey="Locarnini S" first="Stephen" last="Locarnini">Stephen Locarnini</name><name sortKey="Revill, Peter A" sort="Revill, Peter A" uniqKey="Revill P" first="Peter A" last="Revill">Peter A. Revill</name><name sortKey="Rosenberg, Gillian" sort="Rosenberg, Gillian" uniqKey="Rosenberg G" first="Gillian" last="Rosenberg">Gillian Rosenberg</name><name sortKey="Sozzi, Vitina" sort="Sozzi, Vitina" uniqKey="Sozzi V" first="Vitina" last="Sozzi">Vitina Sozzi</name><name sortKey="Thompson, Alexander" sort="Thompson, Alexander" uniqKey="Thompson A" first="Alexander" last="Thompson">Alexander Thompson</name><name sortKey="Wong, Darren" sort="Wong, Darren" uniqKey="Wong D" first="Darren" last="Wong">Darren Wong</name><name sortKey="Yuen, Lilly" sort="Yuen, Lilly" uniqKey="Yuen L" first="Lilly" last="Yuen">Lilly Yuen</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Gaggar, Anuj" sort="Gaggar, Anuj" uniqKey="Gaggar A" first="Anuj" last="Gaggar">Anuj Gaggar</name></region><name sortKey="Kitrinos, Kathryn M" sort="Kitrinos, Kathryn M" uniqKey="Kitrinos K" first="Kathryn M" last="Kitrinos">Kathryn M. Kitrinos</name><name sortKey="Subramanian, G Mani" sort="Subramanian, G Mani" uniqKey="Subramanian G" first="G Mani" last="Subramanian">G Mani Subramanian</name></country><country name="France"><noRegion><name sortKey="Marcellin, Patrick" sort="Marcellin, Patrick" uniqKey="Marcellin P" first="Patrick" last="Marcellin">Patrick Marcellin</name></noRegion></country><country name="Espagne"><region name="Catalogne"><name sortKey="Buti, Maria" sort="Buti, Maria" uniqKey="Buti M" first="Maria" last="Buti">Maria Buti</name></region></country><country name="Canada"><noRegion><name sortKey="Janssen, Harry L A" sort="Janssen, Harry L A" uniqKey="Janssen H" first="Harry L A" last="Janssen">Harry L A. Janssen</name></noRegion></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Gane, Ed" sort="Gane, Ed" uniqKey="Gane E" first="Ed" last="Gane">Ed Gane</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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